Methotrexate and trimethoprim-sulphamethoxazole: extremely serious and life-threatening combination
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چکیده
منابع مشابه
Treatment of chancroid. A comparison of sulphamethoxazole and trimethoprim-sulphamethoxazole.
Since sulphonamides are no longer predictably effective in the treatment of chancroid the combination of trimethoprim-sulphamethoxazole (TMP-SMX) was evaluated to identify other effective regimens. One hundred and nine patients with genital ulcers (75 men and 34 women) seen at the Special Treatment Clinic in Nairobi, Kenya, were randomly assigned to treatment with a seven day course of either s...
متن کاملBacterial endocarditis over prosthetic valves treated with trimethoprim-sulphamethoxazole combination.
During the past few years a number of reports have indicated the therapeutic effectiveness of the new synthetic chemotherapeutic agent trimethoprim (2,4-diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine) used in combination with sulphamethoxazole in a wide range of bacterial infections (Noall, Sewards, and Waterworth, i962; Schneider et al., i965; Akinkugbe et al., I968; Hughes, I969). Staphylococc...
متن کاملLife-Threatening Thrombocytopenia Secondary to Trimethoprim/Sulfamethoxazole
Thrombocytopenia is an uncommon side effect of trimethoprim/sulfamethoxazole (TMP/SMX) when given in the usual recommended adult dosage. We report a case of severe and possibly life-threatening thrombocytopenia associated with TMP/SMX therapy. A 92-year-old female presented after a mechanical fall and subsequent intractable bleeding from a laceration on her left leg. She had a history of cellul...
متن کاملAcute brucellosis treated with trimethoprim and sulphamethoxazole.
Four patients with acute brucellosis are described, none of whom had any connexion with farming or milk industry, the source of infection being different in each case. The diagnosis was made by serological tests, and in three of the four cases was confirmed by positive cultures from bone marrow (one case) and liver biopsy (two cases). Treatment with the combination of trimethoprim/sulphamethoxa...
متن کاملTrimethoprim-sulphamethoxazole in enteric fevers.
Clinical improvement was rapid in all 13 patients with enteric fever and one with Brucella abortus infection treated with trimethoprim-sulphamethoxazole. There were no side-effects of the treatment and it was found easy to administer to toxic and delirious patients.
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ژورنال
عنوان ژورنال: Journal of Clinical Pharmacy and Therapeutics
سال: 2013
ISSN: 0269-4727
DOI: 10.1111/jcpt.12060